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Rheumatoid Arthritis (RA)Definition: Chronic, systemic inflammatory disorder primarily affecting synovial jointsClinical features:Symmetric polyarthritis (hands, wrists, feet)Morning stiffness > 1 hourExtra-articular manifestations (nodules, vasculitis, lung involvement)Joint deformities:Swan neck deformityBoutonni%u00e8re deformityUlnar deviation of fingersInvestigations: Rheumatoid factor (RF) and anti-CCP antibodiesElevated ESR and CRPX-rays: joint space narrowing, erosionsTreatment: DMARDs (methotrexate, sulfasalazine, hydroxychloroquine)Biologics (TNF inhibitors, rituximab, tocilizumab)NSAIDs and corticosteroids for symptom control
