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Eosinophilic Granulomatosis with Polyangiitis (EGPA, Churg-Strauss Syndrome)%u2022Systemic vasculitis associated with asthma and eosinophiliaDefinition:%u2022Asthma (often late-onset)%u2022Allergic rhinitis, nasal polyps%u2022Peripheral neuropathy%u2022Skin lesions (purpura, nodules)%u2022Cardiac involvement%u2022Gastrointestinal symptomsClinical features:%u2022Marked peripheral eosinophilia%u2022Elevated IgE%u2022Positive p-ANCA (in 30-40% of cases)%u2022Tissue biopsy: eosinophilic vasculitisInvestigations:%u2022Corticosteroids%u2022Cyclophosphamide (for severe disease)%u2022Mepolizumab (anti-IL-5 therapy)Treatment:
