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Systemic Sclerosis (Scleroderma)%u2022Autoimmune disorder characterized by fibrosis of skin and internal organsDefinition:%u2022Anti-Scl-70 (anti-topoisomerase I)Key autoantibody:%u2022Skin thickening and tightening%u2022Raynaud's phenomenon%u2022Gastrointestinal involvement%u2022Pulmonary fibrosis%u2022Renal crisisClinical features:%u2022Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, Telangiectasia%u2022Associated autoantibody: Anti-centromereCREST syndrome: Limited form of systemic sclerosisThis Photo by Unknown Author is licensed under CC BY-SA
