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Primary Biliary Cirrhosis (PBC)Definition:%u2022 Chronic autoimmune liver disease leading to destruction of intrahepatic bile ductsKey autoantibody:%u2022 Anti-mitochondrial antibody (AMA)Clinical features:%u2022 Fatigue, pruritus%u2022 Jaundice%u2022 Hepatomegaly%u2022 XanthomasInvestigations:%u2022 Elevated alkaline phosphatase, positive AMATreatment:%u2022 Ursodeoxycholic acid, management of complications
