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Question 18A patient with metastatic melanoma develops vitiligo-like depigmentation. What does this likely indicate?A. Disease progressionB. Immune-related adverse eventC. Favorable prognostic signD. Vitamin B12 deficiencyE. Hormonal imbalanceAnswer: Favorable prognostic signExplanation: The development of vitiligo-like depigmentation in melanoma patients is associated with a favorable prognosis, likely due to an immune response against melanocytes.