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Question 17Which of the following is the most appropriate first-line systemic therapy for HER2-positive metastatic breast cancer?A. TamoxifenB. AnastrozoleC. Trastuzumab + chemotherapyD. BevacizumabE. EverolimusAnswer: Trastuzumab + chemotherapyExplanation: Trastuzumab (Herceptin) in combination with chemotherapy is the standard first-line treatment for HER2-positive metastatic breast cancer.
