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Whipple's Disease%u2022 Rare multisystem disorder%u2022 Caused by Tropheryma whippelii infectionFacts:%u2022 Malabsorption:%u2022 weight loss and diarrhea%u2022 Large joint arthralgia%u2022 Lymphadenopathy%u2022 Skin hyperpigmentation and photosensitivity%u2022 Pleurisy%u2022 Pericarditis%u2022 Neurological symptoms (rare): ophthalmoplegia, dementia, seizure, ataxia, myoclonusClinical Features:%u2022 Jejunal biopsy:%u2022 stunted villi, deposition of macrophages containing%u2022 Periodic acid-Schiff (PAS) granulesInvestigations:%u2022 Co-trimoxazole for one year, preceded by a course of IV penicillinTreatment:
