Page 51 - Demo

Paget's Disease%u2022 Definition: Excessive bone breakdown followed by disorganized new bone formation%u2022 Presentation:%u2022 Bone pain%u2022 Pathological fracture%u2022 Deafness and tinnitus (compression of CN VIII)%u2022 Laboratory findings:%u2022 Increased Alkaline phosphatase%u2022 Normal calcium, phosphate, and PTH%u2022 X-ray findings:%u2022 Cotton wool pattern in the skull%u2022 Osteolytic lesions%u2022 Management:%u2022 Paracetamol and NSAIDs for pain%u2022 Bisphosphonates to reduce bone resorption (e.g., zoledronic acid)This Photo by Unknown Author is licensed under CC BY-SA