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Case Study 4: Unexplained Weight Loss%u2022 Patient: 80-year-old male%u2022 Presentation: 15 lbs weight loss in 3 months, poor appetite, fatigue%u2022 Past Medical History: COPD, Ex-smoker%u2022 Clincher: Rule out Malignancy%u2022 Rationale:%u2022 Unexplained weight loss in elderly is red flag for underlying disease%u2022 History of smoking and COPD increases risk of lung cancer%u2022 Systemic symptoms (fatigue, appetite loss) suggest possible malignancy

