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Case Study 4: AcromegalyPatient:%u2022A 45-year-old man presents with enlargement of hands and feet, coarsening of facial features, and headaches.Findings:%u2022IGF-1: elevated%u2022Failure to suppress GH on oral glucose tolerance test%u2022MRI: pituitary macroadenomaDiagnosis:%u2022AcromegalyTreatment:%u2022Transsphenoidal surgery to remove the pituitary tumor%u2022Somatostatin analogs (e.g., octreotide) if surgery incomplete%u2022GH receptor antagonist (pegvisomant) if needed%u2022Radiotherapy for residual tumor%u2022Management of complications (diabetes, hypertension, sleep apnea) This Photo by Unknown Author is licensed under CC BY-NC-ND

