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Sepsis: Definition and Red FlagsDefinition:%u2022 Life-threatening organ dysfunction due to dysregulated host response to infectionRed Flags (NICE criteria):%u2022 Systolic BP <90 mmHg (or >40 mmHg fall from baseline)%u2022 Heart rate >130 beats per minute%u2022 SpO2 <91%%u2022 Respiratory rate >25/min%u2022 Responds only to voice or pain/unresponsive%u2022 Lactate >2.0 mmol/L
